Case Studies: Real TTE Applications

We'll examine three real TTE applications:

Case	Question	Data	Methods
1. NHEFS	Smoking cessation → weight	Cohort	IPW, g-formula
2. Statins	Statin initiation → CVD	Claims	Clone-censor-weight
3. Cancer	Adjuvant chemo → survival	Registry	Sequential trials

Each case illustrates:

• Target trial specification
• Emulation challenges
• Analytic approaches
• Bias considerations